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Charles L Bidgood on Muck Rack

Charles L Bidgood

As seen in: Nature, BioRxiv
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Articles

Targeting valine catabolism to inhibit metabolic reprogramming in prostate cancer - Cell Death & Disease

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By Charles L Bidgood, Lisa K. Philp, Anja Rockstroh, Martin C Sadowski
| Nature Verified
Abstract Metabolic reprogramming and energetic rewiring are hallmarks of cancer that fuel disease progression and facilitate therapy evasion. The remodelling of oxidative phosphorylation and enhanced lipogenesis have previously been characterised as key metabolic features of prostate cancer (PCa).
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Valine Catabolism Drives Bioenergetic and Lipogenic Fuel Plasticity in Prostate Cancer

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By Lisa K. Philp, Anja Rockstroh, Charles L Bidgood, Melanie Lehman
| BioRxiv
Abstract Metabolic reprogramming is a hallmark of cancer and fundamental for disease progression. The remodelling of oxidative phosphorylation and enhanced lipogenesis are key characteristics of prostate cancer (PCa). Recently, succinate-dependent mitochondrial reprogramming was identified in high-grade prostate tumours with upregulation of enzymes associated with branched-chain amino acid (BCAA) catabolism.
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