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Articles by Charles Simone
Proton Beam Therapy for Testicular Seminoma: Clinical Outcomes and Toxicity From the Proton Collaborative Group Prospective Registry.
Testicular seminoma predominantly affects young men, and while photon-based radiotherapy achieves excellent disease control, concerns about late effects, including secondary malignancies, have driven interest in proton beam therapy (PBT) as a way to improve dose conformality and spare normal tissue. Prospective clinical data for PBT in seminoma, however, remain scarce.
Adjuvant Nivolumab vs Observation in Resected Non–Small Cell Lung Cancer : A Randomized Clinical Trial
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Adjuvant Nivolumab vs Observation in Resected Non–Small Cell Lung Cancer: A Randomized Clinical Trial Supplement 1. Supplement 2. eFigure 1. Disease-free survival sensitivity analysis excluding new primary lung cancers eFigure 2. Disease-free survival in patients with negative and low tumoral PD-L1 eTable 1. Grade 3-5 Treatment-related Toxicities per CTCAE v4.0 eTable 2. Treatment-related Grade 3-5 Events Occurring in ≥ 1% of patients (n,%) Supplement 3.
By Jamie E. Chaft, Zhuoxin Sun, Charles M. Rudin, Charles Simone, Kurt R. Oettel, David Kozono, Rajitha Sunkara, Bryan Faller, James M. Isbell, Vladimir Hugec, Jeffrey M. Clarke, Ramaswamy Govindan, Jacob Sands, John Heymach, Luis E Raez, Shakun Malik, Thomas E. Stinchcombe, Sumithra J. Mandrekar, Jeffrey Bradley, David E. Gerber, Everett E Vokes, David Gandara, Charles Staley, Suresh S. Ramalingam, Onkar V. Khullar, Asheesh Shipstone, Eric C. McGary, Ashita Talsania
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JAMA: Journal of the American Medical Association
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Challenges and Opportunities in Evaluating Novel Drug-Radiotherapy Combinations
Specialty Please choose I'm not a medical professional. Allergy and Immunology Anatomy Anesthesiology Biostatistics Cardiac/Thoracic/Vascular Surgery Cardiology Critical Care Dentistry Dermatology Diabetes and Endocrinology Emergency Medicine Epidemiology and Public Health Family Medicine Forensic Medicine Gastroenterology General Practice Genetics Geriatrics Health Policy Hematology HIV/AIDS Hospital-based Medicine I'm not a medical professional.
Novel use of peak optimized particle therapy for the delivery of three-dimensional spatially fractionated radiotherapy
Abstract Spatially fractionated radiotherapy (SFRT) has been delivered safely and effectively mostly utilizing beamlets of megavoltage photons in recent years. Particle therapy offers the promise of improved dose distributions with less exposure of surrounding normal tissues. However, most efforts have focused on mimicking the beamlets of traditional SFRT two-dimensional therapy (also known as GRID), potentially sacrificing advantages that could be achieved with scanned particle beams.
Important Actionable Clinical Physiological Consequences of a Patent Foramen Ovale (PFO) other than Stroke
Submitted: 16 September 2025 Posted: 19 September 2025 You are already at the latest version The work-up to detect a Patent Foramen Ovale (PFO) is usually done after a patient has a stroke.
Efficacy and safety of transcutaneous auricular vagus nerve stimulation plus pregabalin for radiotherapy-related neuropathic pain in patients with head and neck cancer (RELAX): a phase 2 randomised trial
Keywords Radiotherapy Radiotherapy-related neuropathic pain Head and neck cancer Transcutaneous auricular vagus nerve stimulation Pregabalin Randomised clinical trial Evidence before this study We searched PubMed from database inception to Dec 31, 2023 using the search terms: (“Head and Neck Neoplasms” [Mesh] OR “Head and Neck Cancer” [Title/Abstract]) AND (“Radiotherapy” [Mesh] OR “Radiotherapy” [Title/Abstract])) AND (pain [Title/Abstract]); (“Vagus Nerve Stimulation” [Mesh]) AND (“Pain...
American Radium Society™ Appropriate Use Criteria Systematic Review and Guidelines on Reirradiation for Non-small Cell Lung Cancer Executive Summary
1New York Proton Center, New York, NY 2Memorial Sloan Kettering Cancer Center, New York, NY 3City of Hope Comprehensive Cancer Center, Duarte, CA 4Henry Ford Cancer Institute, Detroit, MI 5The University of Texas, M.D. Anderson Cancer Center, Houston, TX 6The University of Chicago, Chicago, IL 7Fox Chase Comprehensive Cancer Center, Philadelphia, PA 8City of Hope Cancer Center Atlanta, Atlanta, GA 9MHP Radiation Oncology Institute/GenesisCare USA, Farmington Hills, MI 10UH Cleveland Medical...
The fractionation dependence of tumor control in proton therapy for early-stage non-small cell lung cancer
Abstract Purpose: The relative biological effectiveness (RBE) of tumor control for proton beam therapy (PBT) compared to photon radiotherapy (RT) is typically assumed to be independent of fractionation. To test this, we modeled published PBT outcome results for early-stage non-small cell lung cancer (NSCLC) treatments across a range of fractionation schedules. Materials and Methods: All published and analyzable cohorts were included (399 patients, 413 treated lesions).
Refining multimodal strategies for locally advanced NSCLC - Authors' reply
FREE with registration! Log in or register to access the full article. References 1. Heinzerling, JH ∙ Mileham, KF ∙ Robinson, MM ∙ et al. Primary lung tumour stereotactic body radiotherapy followed by concurrent mediastinal chemoradiotherapy and adjuvant immunotherapy for locally advanced non-small-cell lung cancer: a multicentre, single-arm, phase 2 trial Lancet Oncol. 2025; 26:85-97 2. Antonia, SJ ∙ Villegas, A ∙ Daniel, D ∙ et al.
Enhancing Outcomes in Locally Advanced Non-Small Cell Lung Cancer Through Stereotactic Dose Escalation
Get full text access Log in, subscribe or purchase for full access. References Antonia, SJ ∙ Villegas, A ∙ Daniel, D ... Overall survival with durvalumab after chemoradiotherapy in stage III NSCLC N Engl J Med. 2018; 379:2342-2350 Machtay, M ∙ Paulus, R ∙ Moughan, J ... Defining local-regional control and its importance in locally advanced non-small cell lung carcinoma J Thorac Oncol. 2012; 7:716-722 Bradley, JD ∙ Paulus, R ∙ Komaki, R ...
A novel dose rate optimization method to maximize ultra-high dose rate coverage of critical organs-at-risk without compromising dosimetry metrics in proton pencil beam scanning FLASH radiotherapy
Abstract To investigate a dose rate optimization framework based on the spot scanning patterns to improve ultra-high dose rate coverage of critical organs-at-risk (OARs) for proton PBS FLASH radiotherapy, and to present implementation of a genetic algorithm (GA) method for spot sequence optimization to achieve PBS FLASH dose rate optimization under relatively low nozzle beam currents.
Autonomous Tumor Signature Extraction Applied to Spatially Registered Bi-Parametric MRI to Predict Prostate Tumor Aggressiveness: A Pilot Study
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
A novel inverse algorithm to solve IPO-IMPT of proton FLASH therapy with sparse filters
Abstract Purpose:The recently proposed Integrated Physical Optimization Intensity Modulated Proton Therapy (IPO-IMPT) framework allows simultaneous optimization of dose, dose rate, and linear energy transfer (LET) for FLASH treatment planning. Finding solutions to IPO-IMPT is difficult due to computational intensiveness.
In Regard to Dupere et al.
Dupere et al 1 Dupere JM Lucido JJ Breen WG et al. Pencil beam scanning proton therapy for pregnant patients with brain and head and neck cancers. Int J Radiat Oncol Biol Phys. 118: 853-858 compared equivalent doses delivered to the fetus between photon-based therapy and pencil beam scanning proton therapy (PBS-PT) for 7 patients with brain and head and neck cancer.
Bacterial Decolonization for Prevention of Radiation Dermatitis-Fragility Index Analysis
Bacterial Decolonization for Prevention of Radiation Dermatitis Yana Kost, BA; Alana Deutsch, MD; Karolina Mieczkowska, MD; Roya Nazarian, MD; Ahava Muskat, BA; H. Dean Hosgood, PhD; Juan Lin, PhD; Johanna P. Daily, MS, MD; Nitin Ohri, MD, MS; Rafi Kabarriti, MD; Kosaku Shinoda, PhD; Beth N. McLellan, MD To the Editor The randomized clinical trial by Kost et al1 reported recently in JAMA Oncology compared bacterial decolonization to standard of care for the prevention of radiation dermatitis.
Diagnostics | Free Full-Text | Relationship between Eccentricity and Volume Determined by Spectral Algorithms Applied to Spatially Registered Bi-Parametric MRI and Prostate Tumor Aggressiveness: A Pilot Study
2. Materials and Methods 2.1. Overview Figure 1 schematically shows how this study compared metrics related to prostate tumor aggressiveness. Specifically, the International Society of Urological Pathology (ISUP) grade [20] clinically defines cases of prostate cancer as either clinically significant prostate cancer (CsPCa where ISUP ≧2) or clinically insignificant prostate cancer (CiPCa where ISUP < 2).
Neoadjuvant SBRT combined with immunotherapy in NSCLC: from mechanisms to therapy
1Department of Pathology, Xianyang Central Hospital, Xianyang, China 2Department of Pathology, Division of Experimental Diagnostic, KingMed Medical Laboratory (Xi’an) Co., Ltd., Xi’an, China 3Department of Pathology, Xi’an Central Hospital, Xi’an, China 4Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an, China The utilisation of neoadjuvant immunotherapy has demonstrated promising preliminary clinical outcomes for early-stage resectable non-small-cell...
Application of Spectral Algorithm Applied to Spatially Registered Bi-Parametric MRI to Predict Prostate Tumor Aggressiveness: A Pilot Study
4. Discussion This is the first study to apply and test hyperspectral approaches for assessing tumor aggressiveness on spatially registered bi-parametric MRI. This study examined 42 consecutive patients and found high correlation coefficients for linear fits between certain processed SCR, z-score, and the ISUP grade.
Resveratrol analog, triacetylresveratrol, a potential immunomodulator of lung adenocarcinoma immunotherapy combination therapies
Introduction Lung cancer is one of the most common malignancies worldwide (1). It is the most prevalent malignancy in China and the second most common malignancy in the United States, as well as being the leading cause of cancer deaths in both countries (2). Scientists and doctors have made major breakthroughs in the treatment of various types of lung cancer, but there is still a long way to go.
The Impact of Durvalumab on Local Regional Control in Stage III Non-Small Cell Lung Cancers Treated with Chemoradiation and on KEAP1/NFE2L2 Mutant Tumors
This paper is only available as a PDF. To read, Please Download here. Abstract Introduction KEAP1/NFE2L2 mutant NSCLCs are chemoradiation-resistant and at high-risk for local-regional failure (LRF) after concurrent chemoradiation (cCRT). To elucidate the impact of durvalumab on local-regional control, we assessed LRF in NSCLC patients treated with cCRT with and without durvalumab.
Managing Oligoprogressive Malignant Pleural Mesothelioma with Stereotactic Body Radiation Therapy
Andrew R. Barsky Andrew R. Barsky Affiliations Department of Radiation Oncology, Hospital of University of Pennsylvania, PCAM 2-West, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, United States Search for articles by this author Nikhil Yegya-Raman Nikhil Yegya-Raman Affiliations Department of Radiation Oncology, Hospital of University of Pennsylvania, PCAM 2-West, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, United States Search for articles by this author Sharyn I. Katz Sharyn I.
Deferring a Change in the Standard of Care for Small Cell Lung Cancer Brain Metastases
[Skip to Navigation Landing] Original Investigation Evaluation of First-line Radiosurgery vs Whole-Brain Radiotherapy for Small Cell Lung Cancer Brain Metastases Chad G. Rusthoven, MD; Masaaki Yamamoto, MD, PhD; Denise Bernhardt, MD; Derek E. Smith, MS; Dexiang Gao, PhD; Toru Serizawa, MD, PhD; Shoji Yomo, MD, PhD; Hitoshi Aiyama, MD; Yoshinori Higuchi, MD, PhD; Takashi Shuto, MD, PhD; Atsuya Akabane, MD, PhD; Yasunori Sato, PhD; Ajay Niranjan, MD; Andrew M. Faramand, MD; L.
Assessing Expression of PD-L1 in Tumor-Associated Macrophages-Reply
In Reply We would like to thank Zhang et al for their interest in our recent phase 1 nonrandomized controlled trial of chemoradiotherapy with concurrent pembrolizumab for the treatment of locally advanced non–small cell lung cancer (NSCLC)1 and are appreciative of their thoughtful inquiries regarding this work. We would like to address their points in order, as follows.
American Radium Society Appropriate Use Criteria on Radiation Therapy for Extensive-Stage SCLC
Abstract Introduction The standard-of-care therapy for extensive-stage SCLC has recently changed with the results of two large randomized trials revealing improved survival with the addition of immunotherapy to first-line platinum or etoposide chemotherapy. This has led to a lack of clarity around the role of consolidative thoracic radiation and prophylactic cranial irradiation in the setting of chemoimmunotherapy.
Cancer treatment can’t wait out the COVID crisis
For the past five months, the overwhelming impact of the global coronavirus pandemic on our lives has created an untenable scenario: Care for other life-threatening conditions, like cancer, the deadliest disease for Americans under 65 years, has been effectively put on hold. Beginning in March, cancer surgeries and screenings plummeted as hospitals reoriented their operations to serve on the front lines of our unprecedented public health emergency.
Lymphangitic carcinomatosis: a common radiographic manifestation of local failure following extended pleurectomy/decortication in patients with malignant pleural mesothelioma
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Fig. 1 Appearance of MPM lymphangitic carcinomatosis on computed tomography (CT). (a.) An axial image of a unenhanced CT (lung windows) in a 61 year old male and (b) axial and sagittal images in a 62 year old male both demonstrating extensive interlobular septal thickening typical of LC. Both patients have biopsy proven MPM s/p EPD on the left with recurrent disease.
Downstream Effect of a Proton Treatment Center on an Academic Medical Center
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Fig. 1 Trends in the number of radiation fractions (A) and new starts (B) at the academic medical center (AMC), community-based centers (CBC1 and CBC2), and proton treatment center (PC) from fiscal year 2015 (FY15) through FY17. *PC opened in February of FY16. Fig.
Dr. Charles Simone
In the first half, Dr. Charles Simone discussed various medical problems and diseases and the preventative measures people can take to stay healthy, and touched on the recent Ebola outbreak in Africa. In the latter half, psychic medium Helene Olsen, a licensed... More »
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