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Charles W. Dobard on Muck Rack

Charles W. Dobard

As seen in: Nature, EBioMedicine
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Articles

Author Correction: Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal SHIV infection - Nature Communications

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By Andres Wong-Sam, Stephanie Montgomery, Charles W. Dobard, J. Victor Garcia
| Nature Verified
Correction to: Nature Communications https://doi.org/10.1038/s41467-023-36330-5, published online 09 February 2023 The original version of this Article contained an error in the third and fourth sentence of the Methods section under heading ‘SHIV challenge study in rhesus macaques’, which incorrectly read ‘The final challenge stock was diluted to 10 TCID50 and stored individually as 1mL aliquots in liquid nitrogen and thawed prior to each rectal challenge.
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Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal SHIV infection - Nature Communications

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By Stephanie Montgomery, Charles W. Dobard, J. Victor Garcia, Andres Wong-Sam
| Nature Verified
Abstract Ultra-long-acting delivery platforms for HIV pre-exposure prophylaxis (PrEP) may increase adherence and maximize public health benefit. We report on an injectable, biodegradable, and removable in-situ forming implant (ISFI) that is administered subcutaneously and can release the integrase inhibitor cabotegravir (CAB) above protective benchmarks for more than 6 months. CAB ISFIs are well-tolerated in female mice and female macaques showing no signs of toxicity or chronic inflammation.
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Single dose topical inserts containing tenofovir alafenamide fumarate and elvitegravir provide pre- and post-exposure protection against vaginal SHIV infection in macaques

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By M. Melissa Peet, Angela Holder, Charles W. Dobard, Kenji Nishiura
| EBioMedicine Verified
Summary Background Vaginal products for HIV prevention that can be used on-demand before or after sex may be a preferable option for women with low frequency or unplanned sexual activity or who prefer not to use daily or long-acting pre-exposure prophylaxis (PrEP).
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