Charlotte Park

Synthesis and SAR We began our current effort with a high-throughput screen (HTS) identifying VU0641491 and VU0641483 as weak M 4 PAMs with potencies in the micromolar range ( Figure 1 ). Following an investigation into recent research in the field, we came across a structurally similar series which incorporates a 2-methoxy-5-(piperidin-4-yloxy)pyridine moiety.