Giredestrant, a next-generation oral selective estrogen receptor degrader (SERD) and full antagonist, significantly improved invasive disease–free survival as adjuvant treatment for patients with estrogen receptor–positive, HER2-negative early breast cancer compared with standard-of-care endocrine therapy, according to data presented at the 2025 San Antonio Breast Cancer Symposium (SABCS).1 Results from the global, randomized lidERA Breast Cancer trial position giredestrant as a potential new...