Chavin Buasakdi on Muck Rack

Chavin Buasakdi

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Articles

Optimizing PDIA1 Inhibition as a Strategy to Inhibit NLRP3 Inflammasome Activation and Activity

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By Chavin Buasakdi, Caroline Stanton, Prerona Bora, Priyadarshini Chatterjee
| dx.doi.org
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Optimizing PDIA1 Inhibition as a Strategy to Inhibit NLRP3 Inflammasome Activation and Activity

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By Chavin Buasakdi, Caroline Stanton, Prerona Bora
| biorxiv.org
Abstract The NLRP3 inflammasome is a protein complex that promotes pro-inflammatory signaling as part of the innate immune response. Hyperactivation of the NLRP3 inflammasome has been implicated in many inflammatory and neurodegenerative diseases, leading to significant effort in developing strategies to limit its activation to intervene in these disorders.
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The Glycolytic Metabolite Methylglyoxal Covalently Inactivates the NLRP3 Inflammasome.

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By Caroline Stanton, Jie Sun, Chavin Buasakdi, Ian Levitan
| biorxiv.org
Abstract The NLRP3 inflammasome promotes inflammation in disease, yet the full repertoire of mechanisms regulating its activity are not well delineated. Among established regulatory mechanisms, covalent modification of NLRP3 has emerged as a common route for pharmacological inactivation of this protein.
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