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Articles by Chen Du
LENG8 granule regulates alternative polyadenylation in mammals
Abstract Membraneless organelles (MLOs) participate in multiple cellular processes and layers of gene regulation. Alternative polyadenylation (APA) represents a pervasive gene regulatory mechanism that generates distinct 3′ untranslated regions (UTRs) in transcripts. However, whether specific MLOs exist in mammals to regulate APA remains largely unknown. Here, we unveil a nuclear body, termed the LENG8 granule (G granule), that functions as an active hub for APA regulation.
Single-Cell Annotation and Localization via Integrating Spatial Transcriptomics Maps the Mouse Ocular Atlas and RAO Dynamics
1 Introduction Precise characterization of cellular heterogeneity and spatial organization is fundamental to understanding tissue development [1-3], homeostasis [4-6], and disease pathogenesis [7-10]. Although single-cell RNA sequencing (scRNA-seq) has revolutionized the identification of diverse cell types across organs, its lack of spatial context hinders the accurate annotation of cell types and the interpretation of their functions, especially in complex or poorly characterized tissues.
Low Flight | Wang Jibing
Who prescribes that with wings spread one must fly high Low flight is also a flight With wind rustling like birds’ chirps And wheels speeding like shooting stars The meal delivery note attached to a takeout In clear black and white symbolizes urgency Like a legal document and a magic incantation From the three hundred and sixty industries And from the twenty-four solar terms A time cruncher catches sixty-one minutes from an hour And delivers tenderness racing against time They pave the second...
Stable Isotope Characteristics and Recharge Mechanisms of River, Lake and Groundwater by Precipitation in the Hulun Lake Basin
1 Introduction Global climate change intensifies the volatility of water resources (Moghadam et al. 2023; Wang et al. 2024), underscoring the growing conflict between the development and utilisation of water resources and their ecological and environmental benefits.
Impact of continuity of care under the model of healthcare integration on treatment outcomes and prognostic recovery of orthodontic patients
1 Introduction Malocclusion is one of the most serious oral problems after dental caries and periodontal disease. According to statistics, the prevalence of malocclusion among children and adolescents ranges from 39 to 93% (1, 2). In China, the prevalence of malocclusion is about 91.20%, which not only seriously affects the esthetic appearance of the teeth, but also poses greater threats to periodontal health, mental health and physical health (3).
The Real Divide: Totalitarianism is our common enemy
A reflection from behind the firewall: on why the world’s greatest danger is not the clash between East and West, but the deepening misunderstanding between peoples — and the silence imposed by authoritarian fear. I first stumbled into the ruins of the world through an archive. Not a library, nor a classroom, but a digital sanctuary — the Internet Archive, quietly preserving what entire regimes have tried to erase: memory, continuity, connection.
ACRs: retos y oportunidades para la gobernanza del comercio mundial
Ayuda Buscar en la ayuda Buscar en la ayuda ACRs: retos y oportunidades para la gobernanza del comercio mundial Deng, Pan [1] ; Du, Chen [1] [1] Universidad de Ciencias Políticas y de Derecho de China, Beijing, República Popular de China. Localización: Revista Centroamericana de Administración Pública, ISSN-e 2215-3047, ISSN 1409-0937, Nº. 87, 2024 (Ejemplar dedicado a: Globalización y Desglobalización), págs.
Instantaneous Self‐Healing Chitosan Hydrogels with Enhanced Drug Leakage Resistance for Infected Stretchable Wounds Healing
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202409641-sup-0001-SuppMat.docx29.5 MB Supporting Information smll202409641-sup-0002-MovieS1.mp43.1 MB Supporting Information Movie 1 smll202409641-sup-0003-MovieS2.mp42 MB Supporting Information Movie 2 References 1, , , , Sci. China Chem. 2022, 65, 2238. 2, , , , , Chem. Eng. J 2022, 427, 132039. 3, , , , Small 2024, 20, 2305875. 4, , , , , , , , , , Acta. Biomater 2019, 90, 1.
Analysis and validation of Autophagy-related gene biomarkers and immun
Back to Journals » Journal of Inflammation Research » Volume 18 Authors Xiao S , Ding Y, Du C, Lv Y, Yang S, Zheng Q, Wang Z , Zheng Q, Huang M, Xiao Q, Ren Z, Bi G, Yang J Received 7 September 2024 Accepted for publication 15 December 2024 Published 13 January 2025 Volume 2025:18 Pages 549—563 DOI https://doi.org/10.2147/JIR.S495132 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Adam D Bachstetter Shuzhe...
Protein complex heterogeneity and topology revealed by electron capture charge reduction and surface induced dissociation
Abstract Herein, we focus on native mass spectrometry (nMS) combined with a fast, tunable gas-phase charge reduction, electron capture charge reduction (ECCR), and illustrate its utility in the characterization of protein complex topology and glycoprotein heterogeneity. ECCR is illustrated to effectively spread the charge states of tetradecameric GroEL, illustrating Orbitrap m/z measurement out to greater than 100,000 m/z.
Expression Dynamics Indicate Potential Roles of KIF17 for Nuclear Reshaping and Tail Formation during Spermiogenesis in Phascolosoma esculenta
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CDK11 requires a critical activator SAP30BP to regulate pre‐mRNA splicing
Corresponding Author Hong Cheng Key Laboratory of RNA Science and Engineering, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China Contribution: Conceptualization, Resources,...
Techno-economic analysis of 1GW electrolyzer portfolio for Energy Island Bornholm
Chen Du, H. (2023). Techno-economic analysis of 1GW electrolyzer portfolio for Energy Island Bornholm. Universitat Politècnica de València. http://hdl.handle.net/10251/198390 Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/198390 Ficheros en el ítem Nombre: Chen - Techno-economic ...
The polyA tail facilitates splicing of last introns with weak 3′ splice sites via PABPN1
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Endoscopic Resection of Gastrointestinal Stromal Tumors
Surgical resection is regarded as the main modality for the treatment of gastrointestinal stromal tumors (GISTs). With the advancement of endoscopic techniques and the concept of super minimally invasive surgery (SMIS), endoscopic resection has been an alternative option for surgery.
The Effect of Prohibitins on Mitochondrial Function during Octopus tankahkeei Spermiogenesis
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Application of an effective marker‐less augmented reality image guidance method in dental implant surgery
Abstract Background The existing augmented reality (AR) dental implant surgery navigation system usually uses markers to complete image guidance. However, markers often affect dentists' operations and make patients uncomfortable. Methods To solve the problems caused by markers, this paper proposes an effective marker-less image guidance method.
Combining Surface-Induced Dissociation and Charge Detection Mass Spectrometry to Reveal the Native Topology of Heterogeneous Protein Complexes
Download Hi-Res ImageDownload to MS-PowerPointCite This:Anal. Chem. 2023, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Waterproof Flexible Pressure Sensors Based on Electrostatic Self-Assembled MXene/NH2-CNTs for Motion Monitoring and Electronic Skin
Flexible wearable sensors to monitor human movement and for electronic skins must exhibit high sensitivity, a wide detection range, and waterproof characteristics. This work reports a flexible, highly sensitive, and waterproof sponge pressure sensor (SMCM). The sensor is made by assembling SiO2 (S), MXene (M), and NH2-CNTs (C) on the backbone of melamine sponge (M).
Phylogenetic and Spatiotemporal Analyses of Porcine Epidemic Diarrhea Virus in Guangxi, China during 2017–2022
4. Discussion PEDV is a primary swine intestine pathogen that has given rise to serious economic losses for pig production and pork-associated businesses [36]. Vaccines for PEDV have been widely used in pig farms up until now [37,38]. However, CV777-based vaccines cannot offer complete protection from PEDV infection [39]. In this study, 673 samples were collected from 143 pig farms in Guangxi from January 2017 to March 2022.
Emotional Eating among Ghanaian University Students: Associations with Physical and Mental Health Measures
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Studying Oral Tissue via Real-Time High-Resolution Terahertz Spectroscopic Imaging
Abstract Terahertz (THz) waves are extremely sensitive to water content and biological composition (proteins, genes, and metabolites), which are the key regulator of cancer development. Hence, the application of THz spectroscopy and imaging is promising in the field of biomedicine, especially in cancer diagnosis. Currently, the diagnosis of cancer patients (including tumor borders, tumor stage, etc.) mainly rely on optical microscope observation of pathological slices.
IJERPH | Free Full-Text | The Effects of Acute Sleep Curtailment on Salt Taste Measures and Relationships with Energy-Corrected Sodium Intake: A Randomized Cross-Over Trial with Methodology Validation
Open AccessArticle by Chen Du 1, Russell Keast 2, Sze-Yen Tan 3 and Robin M.
Effects of the COVID-19 Pandemic on Health Behaviors of Higher Education Students in Ghana: A Cross-Sectional Study
2. Materials and Methods 2.1. Study Design In this cross-sectional study, undergraduate and postgraduate students from the Kwame Nkrumah University of Science and Technology, Ghana who were at least 18 years old were eligible for enrollment. Students below 18 years of age were excluded. To recruit participants, five departments from each college in the university were randomly selected to be contacted about the study.
Exclusive: Musk finds new Tesla CEO to sleep in Gigafactories for him
Tesla China Tom Zhu Elon Musk Tesla Exclusive: Musk finds new Tesla CEO to sleep in Gigafactories for him Tom Zhu, current Tesla China and APAC head, will continue his long-held tradition of avoiding the spotlight. SHARE BEIJING, Dec. 7 (PingWest) - Elon Musk has decided on the person to take the position as the CEO of Tesla Global, according to trusted sources who spoke to PingWest.
Eco-Friendly Gelatin Based Triboelectric Nanogenerator for Self-Powered PANI Nanorods/NiCo2O4 Nanospheres Ammonia Gas Sensor
Eco-Friendly Gelatin Based Triboelectric Nanogenerator for Self-Powered PANI Nanorods/NiCo2O4 Nanospheres Ammonia Gas Sensor Low-cost and eco-friendly auxiliary energy supply units to power gas sensors are of great significance to various fields. In this work, a gas sensor based on the PANI/NiCo2O4 composite was powered by a gelatin-polyimide based triboelectric nanogenerator (GP-TENG) for the detection of NH3 at room temperature.
Meituan discloses technical and design detail on delivery worker routing algorithm - PingWest
Meituan Food Delivery Algorithms Meituan discloses technical and design detail on delivery worker routing algorithm Chen Du posted on November 8, 2021 2:23 pm As China's first personal data protection law went into effect recently, marking the height of the public's interest in learning about the inner workings of algorithms that dictates our lives, Meituan made some of the details public to address public concern.
Alibaba, Tencent remove NFT reference in digital collectibles platforms
Alibaba, Tencent remove NFT reference in digital collectibles platforms In a move to avoid potentially imminent adversarial actions by the government, both big techs stopped selling digital pictures as "NFT" last weekend. SHARE Update: after publishing, Antchain clarified to PingWest that the platform decided to allow digital collectibles to be freely gifted between "authenticated Alipay users" after they have been held by one user for more than 180 days.
Google shows you the Great Wall of China, no pun intended
Google shows you the Great Wall of China, no pun intended Take a virtual tour of the famous Simatai Great Wall, in the comfort of your home. SHARE Ever wanted to visit the Great Wall of China? Now Google China lets you do that in the comfort of your home. And absolutely no pun intended here before you whip out the GFW jokes.
A good, inclusive internet of China is getting into shape- PingWest
Internet regulation minors elders Live Streaming Online Games A good, inclusive internet of China is getting into shape Chen Du posted on 17 hours agoEditor : Wang Boyuan From the outset, measures may seem like crackdowns on tech, while the bigger picture here is that tech advancements have transformed the way people live, making the world a better place in some regards, creating inequity in others. Now China intends to reduce the disparities.
China’s official anti-fraud app has weird marketing tricks up its sleeves
China’s official anti-fraud app has weird marketing tricks up its sleeves Leaving the old image of forced installation behind, the National Anti-Fraud Center app developed by China's MPS is trying all kinds of guerilla marketing tactics to help people avoid scams. SHARE Recently, the hashtag "how amazing is the national anti-fraud app" became trending on Weibo.
Chinese big tech’s community group-buying scheme is falling apart- PingWest
Chinese big tech’s community group-buying scheme is falling apart The downfall of major big tech players like Chengxin Youxuan and Tongcheng Life indicate that the economy of community group-buying may be at a tipping point, and burning more cash isn't likely going to help make the journey to the bottom smoother. SHARE One after another, companies of China's once-burgeoning community group-buying industry are falling apart.
Protected by new data protection law, Chinese netizens can now say no to algorithms- PingWest
Data Privacy Data Protection Protected by new data protection law, Chinese netizens can now say no to algorithms Chen Du posted on 7 minutes agoEditor : Wang Boyuan Algorithms are no longer safe behind black boxes, as new law orders companies to give users options and be transparent. SHARE In the Season 2 premiere of the dystopian drama series Black Mirror, a woman decided to upload all of her late husband’s data and an uncannily similar humanoid.
Fast self-healing multifunctional polyvinyl alcohol nano-organic composite hydrogel as building blocks for highly sensitive strain/pressure sensors
Fast self-healing multifunctional polyvinyl alcohol nano-organic composite hydrogel as building blocks for highly sensitive strain/pressure sensors The conductive and biocompatible hybrid hydrogel was successfully assembled into an adhesive, flexible wearable sensor for ultra-sensitive human-computer interaction and smart detection, which holds excellent self-healing capability.
In situ polymerized polypyrrole/halloysite nanotubes-silver nanoflowers based wearable pressure sensor with large measurement range and high sensitivity
In situ polymerized polypyrrole/halloysite nanotubes-silver nanoflowers based wearable pressure sensor with large measurement range and high sensitivity Flexible wearable sensors have attracted a lot of attention because of their great potential for applications in wearable medical health detection, human activity detection, and artificial electronic skin. However, achieving both high sensitivity and large measurement range on a single sensor remains a serious challenge.
Cyberattacks target Chinese indie online games for ransom, but developers refuse to let the hackers win- PingWest
Cyberattacks target Chinese indie online games for ransom, but developers refuse to let the hackers win Developers who mounted challenge against the giants and gained the favor of Chinese gamers found their dreams shattered as hackers target indie games specifically.
Chinese regulators to tear down big techs’ protective barriers- PingWest
MIIT Tencent WeChat tech barriers Alibaba Chinese regulators to tear down big techs’ protective barriers Chen Du posted on July 26, 2021 5:13 pmEditor : Wang Boyuan With great pleasure, we at PingWest report that a good riddance is soon to be happening in China’s internet industry, long dominated and manipulated by big techs.
Chinese Big Techs rush to Henan flood relief- PingWest
Donations and free services: Chinese Big Techs rush to Henan flood relief The ongoing disaster showed that the country’s public emergency management apparatus is still lacking technologically, leaving ample opportunities for big techs to help improve upon. SHARE China's Henan Province is suffering from a disastrous flash flood caused by a historical level of precipitation.
Red packet script app fined 4.5 million yuan for violating Tencent's interest- PingWest
WeChat Red packet script app fined 4.5 million yuan for violating Tencent's interest Chen Du posted on July 20, 2021 6:12 pm A court in Beijing known to follow the case law logic has just set an important precedent.
Faced with 500,000 yuan fine, Tencent Music Entertainment to give up exclusive label rights- PingWest
Faced with 500,000 yuan fine, Tencent Music Entertainment to give up exclusive label rights Tencent had already lost exclusivity with the global top 3 labels. Now more of its exclusive licenses with domestic and asian labels, as well as rights to music from popular reality shows, will be stripped away too.
AutoX debuts Gen5, an L4 full self-driving system, becomes 1st Chinese company to do so- PingWest
AutoX Self-driving Waymo AutoX debuts Gen5, an L4 full self-driving system, becomes 1st Chinese company to do so Chen Du posted on July 6, 2021 5:31 pm The company is also the first ever Chinese company to have acquired specific licenses from the California DMV to road test full self-driving cars.
China's new consumer brands are breaking out faster and healthier than ever- PingWest
A combination of market shifts, eagerly accessible venture capital, and an affinity in modern design, forged a new era of fast and healthier growth for the highly sought-after Chinese consumer brands.
Binance's UK operations banned over incompliant derivative traiding- PingWest
Binance Binance's UK operations banned over incompliant derivative traiding Chen Du posted on 3 hours ago While the watchdog can't regular plain cryptocurrency traiding, derivatives are exception since they can be considered as "securities".
step by step towards China's first space station- PingWest
Tiangong space station human spaceflight PinGraphic: step by step towards China's first space station Chen Du posted on 3 hours ago An infographic project to show you how Tiangong came to be. SHARE Editor's note: PinGraphic is a series of infographic projects made by PingWest's Chinese edition.
ByteDance finally makes its ‘secret sauce’ techs available for the public- PingWest
Bytedance Volcano Engine ByteDance finally makes its ‘secret sauce’ techs available for the public Chen Du posted on 13 hours ago Taken and compiled from ByteDance’s various successful products, the data-driven business insight service marks the Chinese tech giant’s renewed ambition in the the enterprise market.
Chinese AI lab challenges Google, OpenAI with a model of 1.75 trillion parameters- PingWest
The model is trained on Chinese supercomputers and boasts 10 times the parameters of OpenAI’s GPT-3. SHARE In the race to build the underlying technologies that can power the next wave of AI revolution, a Chinese lab just toppled OpenAI, the venerated US-based research lab, in terms of who can train a gigantic deep learning model with the most training parameters--as for whether or not there is a race, at least ranking members of the lab believe so.
Miniso registers entity dedicated to lucrative franchising business- PingWest
MINISO Consumer Miniso registers entity dedicated to lucrative franchising business Chen Du posted on 18 hours ago It is very likely that franchising contributes more net profit to Miniso than actually selling goods. SHARE Miniso, the Chinese low-cost "mini department store" chain known for its immensely diverse stock of various consumer products, was recently found to have registered an entity that is reportedly dedicated to its lucrative franchising businesses, PingWest has found.
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