Summary Liver macrophages play critical roles in the pathogenesis of non-alcoholic steatohepatitis (NASH). In this issue of Immunity, Tran et al. and Remmerie et al. reveal that Ly6C hi monocytes in NASH replace dying resident Kupffer cells, while concomitantly are differentiating into distinct lipid associated macrophages. To read this article in full you will need to make a payment Purchase one-time access Read-It-Now Purchase access to all full-text HTML articles for 6 or 36 hr at a low cost.