Chen-yu Zou

Abstract Vocal fold (VF) injury, frequently caused by laryngeal microsurgery, leads to fibrosis and phonation impairment. Effective therapies remain limited, partly due to limited understanding of VF injury mechanisms. Using single-cell RNA sequencing of injured human VFs, we identified marked oxidative stress upregulation in epithelial cells, highlighting the need for epithelial protection and redox modulation.

1 Introduction Uncontrolled bleeding, which may occur during major surgery, war and natural disasters, has been a leading cause for death.[1] And nearly 50% of such deaths could be prevented by effective hemostasis.[2] A great effort has been made to develop hemostatic materials including blood products, coagulation factors, and antifibrinolytics, which have become the standard treatment for acute clinical bleeding.