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Articles by Chenchen Yu
Distinct T cell correlates of COVID-19 risk before and after a second booster in previously SARS-CoV-2 infected versus naïve COVAIL trial participants
Abstract The relationship between SARS-CoV-2-specific T cell responses and COVID-19 risk is incompletely understood, particularly after variant-adapted booster receipt. We assessed Spike-specific and Nucleocapsid-specific CD4+ and CD8+ T cell responses, measured by validated 27-color intracellular cytokine staining assay, as correlates of COVID-19 risk over 6 months in COVAIL recipients of a second SARS-CoV-2 booster on Day 1 (D1).
Corticothalamic circuits drive voluntary physical exercise-mediated relief of surgery-induced negative emotions in mice
Abstract Surgery-induced negative emotions (SINE), such as fear and anxiety, are common clinically and hinder postoperative recovery. Although physical exercise is known to modulate various affective disorders, the underlying mechanisms by which voluntary physical exercise alleviates SINE remain unclear.
BMDnet: an efficient UAV small object detection model via multi-scale feature enhancement and dynamic attention
Abstract Small object detection in UAV aerial images is challenged by significant scale variation, weak edge information, and complex backgrounds. To address these issues, an efficient model termed BMDnet is proposed based on YOLOv11n. The proposed method introduces a collaborative optimization framework from three aspects: feature fusion, feature enhancement, and detection optimization.
Lycorine: From Extraction and Synthesis to Formulation Development—Research Challenges and Advances in Pharmacological Mechanisms and Clinical Translation
Cong Zhang, Chenchen Yu, and Chungang Zhang contributed equally to this study and share first authorship. C.Zhang, C.Yu, C.Zhang, and J.Li, “Lycorine: From Extraction and Synthesis to Formulation Development—Research Challenges and Advances in Pharmacological Mechanisms and Clinical Translation,” Archiv der Pharmazie359 (2026): e70255. https://doi.org/10.1002/ardp.70255. Conflicts of Interest The authors declare no conflicts of interest.
Correlates of severe and delta COVID-19 in a phase 3 trial of the AZD1222 vaccine
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Abstract In the phase 3 AZD1222 COVID-19 vaccine trial, anti-Spike (vaccine-matched and Delta) binding IgG antibody concentration and neutralizing antibody (nAb) titer (vaccine-matched+D614G and Delta), measured four weeks post-dose two (D57), were assessed as correlates of risk of severe COVID-19 and Delta COVID-19 over ~4 to ~13 months (severe) or ~11 months (Delta) post-D57.
By Holly Janes, Youyi Fong, Ying Huang, David Benkeser, Elizabeth Kelly, Ian Hirsch, Ann Marie Stanley, Tonya L Villafana, Christos Petropoulos, Andrew Leith, Bill Webb, Yiwen Lu, Chenchen Yu, Bhavesh Borate, Nima Hejazi, April K. Randhawa, Michele Andrasik, James G. Kublin, Margaret Brewinski Isaacs, Tina Tong, Merlin L. Robb, Lawrence Corey, Kathleen M. Neuzil, Dean Follmann, Ann R Falsey, Magdalena E. Sobieszczyk, Richard A. Koup, Peter Gilbert, Deanne Haugaard, Lars W. P. van der Laan, Mamodikoe Makhene
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Nature
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High Bioavailability Resveratrol Delivery System: A Novel Nutritional Strategy for the Prevention and Alleviation of Rheumatoid Arthritis
1 Introduction Rheumatoid arthritis (RA) is an autoimmune disease marked by progressive, symmetric joint inflammation resulting in cartilage destruction, bone erosion, and disability (Lin et al. 2020). The prevalence of RA varies across different regions, with higher incidence rates commonly found in industrialized countries (Peng et al. 2024). RA affects approximately 0.5%–1% of the adult population, with a significantly higher prevalence in women than in men (Baig et al. 2024).
A Dual-Function Gastroretentive System: Enhancing Ofloxacin Bioavailability via Floating-Bioadhesive Pellets Based on a Hollow Structure Prepared with a Hybrid Polymer Film
Back to Journals » Drug Design, Development and Therapy » Volume 20 Authors Zhang C , Yu C, Zhang L Received 13 January 2026 Accepted for publication 26 May 2026 Published 8 June 2026 Volume 2026:20 589908 DOI https://doi.org/10.2147/DDDT.S589908 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Leonidas Panos Chungang Zhang,1,* Chenchen Yu,2,* Lin Zhang3 1College of Pharmacy, Liaoning University of...
Risk of COVID-19 after natural infection or vaccination.
BACKGROUND: While vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample population to address this issue.
Pharmaceutics | Free Full-Text | Impact of LS Mutation on Pharmacokinetics of Preventive HIV Broadly Neutralizing Monoclonal Antibodies: A Cross-Protocol Analysis of 16 Clinical Trials in People without HIV
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Dietary inflammatory index and renal cancer risk: a prospective study
Dietary inflammatory index and renal cancer risk: a prospective study Background: High dietary inflammatory index (DII®) scores, representing pro-inflammatory diets, have been associated with increased risks for numerous cancers. However, the evidence for renal cancer is limited. In the present study, we aimed to assess the association between DII and renal cancer risk in the Prostate, Lung, Colorectal, and Ovarian (PLCO) cohort.
Degradation and regeneration of Fe-Nx active sites for oxygen reduction reaction: the role of surface oxidation, Fe demetallation and local carbon microporosity
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Antigenic competition in CD4+ T cell responses in a randomized, multicenter, double-blind clinical HIV vaccine trial
Many HIV vaccines aim to generate robust T cell responses, but two new studies show that this is not always straightforward. Chamcha et al. analyzed data from several nonhuman primate vaccine studies with SIV/SHIV challenges and discovered that achieving a certain threshold of vaccine-induced IFN-γ + CD4 T cells lowered vaccine efficacy, possibly by providing target cells for the virus. Kallas et al.
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