Chengnan Li

Abstract Introduction: Disrupted rest-activity rhythm (RAR), an accelerometer-derived measure of the strength and temporal organization of daily behavioral rhythms, has been linked to multiple adverse health outcomes. Given that the development of abdominal aortic aneurysm (AAA) involves chronic inflammation, extracellular matrix degradation, and vascular smooth muscle cell dysfunction, attenuated rest-activity rhythms (RAR) may be associated with AAA risk.

Introduction Chronic kidney disease is a global public health issue, affecting more than 10% of adults worldwide (1). Impaired kidney function is associated with a high risk of cardiovascular disease (CVD) and all-cause mortality (2). Numerous studies have suggested that non-dialysis-dependent kidney dysfunction is closely linked to heart failure, atrial fibrillation, and the incidence of CVD in asymptomatic populations (3, 4).