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Chengnong Guan on Muck Rack

Chengnong Guan

As seen in: Nature
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Articles

JNK acts as a molecular brake of the CDC73 positive feedback loop to modulate osteosarcoma malignant progression via UBR5

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By Xinchen Wang, Hua Tu, Lili Hao, Renjie Hu, Pengchao Zheng, Yuhan Shi, Jianbo Sun, Baoshan Xu, Dingji Li, Huigen Luo, IoHong Lei, Minying Zhu, Chengnong Guan
| Nature Verified
Abstract CDC73 is a well-characterized tumor suppressor regulated by stress stimuli, governing progression of diverse human malignancies. Although previous studies have shown that E3 ubiquitin ligase UBR5 drives CDC73 ubiquitination and degradation to modulate tumorigenesis, the mechanisms by which stress-responsive pathways regulate UBR5-mediated CDC73 inactivation and transcriptional reprogramming remain elusive.
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