Chengpeng Xu on Muck Rack

Chengpeng Xu

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TCL1A mediates DNA methylation defects in recurrent hydatidiform mole with NLRP7 pathogenic variants - Nature Communications

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By Zheng Gao, Qingting Liu, Ting Hu, Xukun Lu, Yu Chen Wu, Dandan Qin, Xiaoxiao Wang, Chen Gu, Jinhong Li, Chengpeng Xu, Dan Zhou, Fan Zhou, Yanling Bai, Xiangjin Kang, Jianqiao Liu, Dong Deng
| Nature Verified
Abstract Pathogenic variants in NLRP7, implicated in 55% of recurrent hydatidiform mole characterized by hypomethylation at maternally methylated imprinted regions, are proposed to disrupt de novo DNA methylation in human oocytes. However, the precise mechanism remains unclear. Here, we identify TCL1A, a DNMT3A inhibitor, as an endogenous NLRP7-interacting partner. The cryo-EM structure of the NLRP7-TCL1A complex reveals its fundamental architecture.
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