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Elesclomol Loaded Copper Oxide Nanoplatform Triggers Cuproptosis to Enhance Antitumor Immunotherapy
1 Introduction Melanoma is the most lethal type of skin cancer and originates from the malignant transformation of melanocytes.[1, 2] Melanoma is the fifth most common cancer worldwide and the leading cause of skin cancer-related death.[3, 4] This disease frequently metastasizes to and can spread to distant organs such as the brain, lung, liver, and bone through lymph nodes and blood vessels.[5, 6] Currently, immune checkpoint inhibitors (ICIs), represented by programmed cell death-1 (PD-1)...
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