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Chengzhu Cao on Muck Rack

Chengzhu Cao

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Articles

Saussurea medusa Maxim extract suppresses triple‑negative breast cancer growth by disrupting mitochondrial lipid metabolism via the PPARα/CPT1A fatty acid oxidation axis

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By Jing Zhao, Ronghua Ma, Ping Jiang, Yanrong Zhang, Haixiu Ma, Haiyan Wang, Juan Ji An, Zhanhai Su, Shoude Zhang, Chengzhu Cao
| Nature Verified
Abstract Triple‑negative breast cancer (TNBC) lacks effective targeted therapies and exhibits pronounced metabolic plasticity. Mitochondrial lipid metabolism and fatty acid oxidation (FAO) represent potential vulnerabilities. We investigated the antitumor activity and mechanism of Saussurea medusa Maxim extract (SMME) in TNBC models. SMME was profiled by HPLC–HRMS. Antitumor phenotypes, including viability, apoptosis, migration, and ultrastructural changes, were evaluated in TNBC cells.
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