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Chenicka Lyn Mangahas on Muck Rack

Chenicka Lyn Mangahas

As seen in: Stem Cell Reports
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By Claudia Raggi, CHU Sainte-Justine, Quang Pham, Marie-Agnès M’Callum, Gaël Cagnone, Bruno Reversade, Jean-Sebastien Joyal, Massimiliano Paganelli, Marie-Agnès M’Callum, Perrine Gaub, Silvia Selleri, Nissan Vida Baratang, Chenicka Lyn Mangahas
| Stem Cell Reports Verified
Highlights • We generated human hepatoblasts and hepatocyte-like cells (HLCs) from pluripotent stem cells • Timed action on Wnt/β-catenin and TGFβ pathways improved maturity and yield of HLCs • Hepatoblasts matured into hepatocytes and bile ducts within complex liver organoids • The protocol is robust and showed potential for scalability and drug testing Summary Pluripotent stem cell (PSC)-derived hepatocyte-like cells (HLCs) have shown great potential as an alternative to primary human...
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