Skip To Main Content
Chenjing Yue on Muck Rack

Chenjing Yue

As seen in: Nature
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Chenjing

Contact Chenjing, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

PRMT6-mediated EZH2 arginine methylation is critical for breast cancer development

|
By Xue Han, Maoxiang Zhang, Chao Lu, Hui XU, shiyu Du, Zhenhai Yu, Chenjing Yue
| Nature Verified
Abstract Enhancer of zeste homologue 2 (EZH2), as a key histone methyltransferase, is elevated in multiple malignant tumours, which leads to poor prognosis. However, the underlying mechanisms for mediation of EZH2 enzyme activity remain elusive. Here, we report that PRMT6 asymmetrically dimethylates EZH2 at R509 to promote the bindings between EZH2 and other core component of the polycomb repressive complex 2 (PRC2), which enhances PRC2 induced methylation of histone H3 at K27.
Open in Who Shared Issue with article?
See all 1 articles