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Articles by Chenwen Li
Decoding Undesirable Inflammatory Responses of Nucleic Acid-Delivering Lipid Nanoparticles
1 Introduction Lipid nanoparticles (LNPs), typically formulated with ionizable lipids, helper lipids, cholesterol, and PEGylated lipids, have revolutionized nucleic acid delivery, as evidenced by the remarkable clinical success of COVID-19 mRNA vaccines [1, 2]. The ionizable lipid-mediated endosomal escape mechanism enables efficient cytosolic delivery of different nucleic acid payloads [3, 4].
Frontiers | Characterization of skin adverse events associated with cetuximab: real-world insights from the two global pharmacovigilance databases of FAERS and VigiAccess
Department of Dermatology, Henan Provincial People’s Hospital, Henan University People’s Hospital, Zhengzhou, China Background: Cetuximab, an IgG1 monoclonal antibody targeting the epidermal growth factor receptor (EGFR), is widely used in metastatic colorectal cancer and other solid tumors. Cutaneous adverse events (AEs) are among its most frequent toxicities, but real-world evidence on their spectrum and risk profile remains limited.
Efficacy and safety of intradermal botulinum toxin A for post-acne erythema: a split-face randomized controlled trial
Dermatology Department, Henan Provincial People's Hospital, Zhengzhou, China Introduction: Post-acne erythema (PAE) is a common aesthetic sequela in patients with acne. Although numerous treatments for PAE have been investigated, the efficacy of intradermal botulinum toxin A (BTX-A) remains controversial. This study aimed to evaluate and compare the efficacy and safety of intradermal BTX-A versus broadband light (BBL) for treating PAE.
A novel mitochondria‐targeting compound exerts therapeutic effects against melanoma by inducing mitochondria‐mediated apoptosis and autophagy in vitro and in vivo
Filename Description tox23896-sup-0001-supinfo.pdfPDF document, 297.4 KB Data S1. Supporting Information. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Engineering of Biodegradable and Excretable Inflammation‐Resolving Materials (Adv. Funct. Mater. 41/2022)
Abstract Bioactive Materials In article number 2205528, Jianxiang Zhang and co-workers report a series of inflammation-resolving biomaterials engineered by integrating different functional modules into a hydrolysable scaffold, which can assemble into anti-inflammatory micelles capable of eliminating reactive oxygen species, releasing bioactive molecules, and simultaneously hydrolyzing into water-soluble and excretable compounds, thereby efficaciously alleviating acute kidney injury and acute...
A reactive oxygen species-responsive antioxidant nanotherapy for the treatment of drug-induced tissue and organ injury
A reactive oxygen species-responsive antioxidant nanotherapy for the treatment of drug-induced tissue and organ injury† Chenwen Li,‡a Ying Hu,‡ab Qiang Nie,‡a Shuguang Chen,c Gang Li,a Lanlan Li,a Sheng Chen,*d Bo Tang*b and Jianxiang Zhang *ae Author affiliations * Corresponding authors a Department of Pharmaceutics, College of Pharmacy, Third Military Medical University (Army Medical University), Chongqing 400038, China E-mail: jxzhang1980@gmail.com b Department of General Surgery,...
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