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Chenying Shu on Muck Rack

Chenying Shu

As seen in: British Pharmacological Society
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Articles

Direct targeting of LYN kinase by fluphenazine triggers ferroptosis to suppress lung adenocarcinoma

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By Yuna Shao, Huiling Zhang, Chenying Shu
| British Pharmacological Society
DARTS drug affinity responsive target stability FAK focal adhesion kinase Flu fluphenazine GPX4 glutathione peroxidase 4 GSH glutathione LUAD lung adenocarcinoma LYN lck/yes-related protein tyrosine kinase MDA malondialdehyde NSCLC non-small cell lung cancer SPR surface plasmon resonance 4-HNE 4-hydroxynonenal What is already known? LUAD has poor prognosis and lacks ideal treatments. Fluphenazine has antipsychotic effects, but its exact molecular mechanism remains unclear. What does this study add?
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