Cherilyn A. Elwell on Muck Rack

Cherilyn A. Elwell

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Global mapping of the Chlamydia trachomatis conventional secreted effector-host interactome reveals CebN interacts with nucleoporins and Rae1 to impede STAT1 nuclear translocation.

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By Shelby E. Andersen, Brianna Steiert, Paige N. McCaslin, Cherilyn A. Elwell
| biorxiv.org
Abstract Chlamydia trachomatis (C.t.), the leading cause of bacterial sexually transmitted infections, employs a type III secretion system (T3SS) to translocate two classes of effectors, inclusion membrane proteins and conventional T3SS (cT3SS) effectors, into the host cell to counter host defense mechanisms. Here we employed three assays to directly evaluate secretion during infection, validating secretion for 23 cT3SS effectors.
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