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Chiahsuan Chin

As seen in: Respiratory Research, Cell Reports Medicine
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Articles

Alveolar epithelial type 2 cell specific loss of IGFBP2 activates inflammation in COVID-19 - Respiratory Research

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By Chiahsuan Chin, Narendra V. Sankpal, Rajat Walia, Michael A. Smith, Michaël Smith, Oliver Eickelberg, Ross Bremner, Thalachallour Mohanakumar, Valentina Pujadas, James Buhrmaster, Ashwini Arjuna, Angara Sureshbabu
| Respiratory Research Verified
To examine the histological changes driven by SARS-CoV-2 infection, we performed H&E and Masson’s trichrome staining in lung regions obtained from patients diagnosed with COVID-ARDS (severe), IPF alone, or IPF with COVID history (moderate). H&E staining analyses revealed abnormal lung structures with heterogeneity in COVID-ARDS patients compared to patients from the other disease groups.
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Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis

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By Byun H.O, Chiahsuan Chin, Ranjithkumar Ravichandran, Kristina Sanborn
| Cell Reports Medicine Verified
Introduction Idiopathic pulmonary fibrosis (IPF) is the most common and severe form of interstitial lung disease, affecting more than 5 million individuals worldwide. 1 Idiopathic pulmonary fibrosis. IPF is a heterogeneous disease often occurring in the elderly, with a median survival rate of less than 3 years. 2 Ley B. Collard H.R. King T.E. Clinical course and prediction of survival in idiopathic pulmonary fibrosis.
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