Chiamaka Miracle Ajah on Muck Rack

Chiamaka Miracle Ajah

As seen in: BMJ Global Health
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Articles

Beyond hematopoietic stem cell transplantation: positioning Africa for scalable uptake of innovative sickle cell therapies

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By Chukwudi Agu, Rodiat Abdulkareem, Chiamaka Miracle Ajah
| BMJ Global Health
Sickle cell disease (SCD) is a major health burden in Africa, with high child mortality and limited treatment options. Hematopoietic stem cell transplantation (HSCT) can cure SCD but is inaccessible due to high costs and limited donors. Emerging gene therapies like CRISPR-Cas9 offer one-time cures using the patient’s own cells, removing donor dependence. Key challenges include affordability, poor infrastructure, lack of regulation and limited access to genetic testing.
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