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Chiara Barizza on Muck Rack

Chiara Barizza

As seen in: Nature
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Articles

Midostaurin response in AML is shaped by a progenitor-like cell state selectively targeted by SMAC mimetics

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By Nona Struyf, Henrik Gezelius, Anders Lundmark, Lucia Pizarro, Mattias Vesterlund, Georgios Mermelekas, Albin Österroos, Anna Bohlin, Sofia Bengtzén, Kerstin Hamberg Levedahl, Rozbeh Jafari, Lukas M Orre, Janne Lehtiö, Päivi Östling, Brinton Seashore-Ludlow, Jessica Nordlund, Sören Lehmann, Olli Kallioniemi, Tom Erkers, Chiara Barizza, Hidde Ploeger
| Nature Verified
Abstract FLT3-mutated acute myeloid leukemia (AML) remains difficult to treat due to frequent resistance to FLT3 inhibitors like midostaurin. In this study, we observed a progenitor-like CD38+CD45RA+ leukemic cell population that may be associated with midostaurin resistance. Midostaurin-resistant cells display disrupted membrane architecture and a shift in signaling from STAT5 to PI3K/AKT, favoring survival over apoptosis.
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