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1. Introduction Cutaneous involvement is a hallmark of systemic sclerosis (SSc); it occurs in most patients and is the most accessible and obvious sign. The extent of skin involvement has been considered relevant for the prognosis of SSc since it is inversely correlated with survival and is considered an important marker of disease severity [1]. However, a recent EUSTAR study has questioned the prognostic value of conventional SSc classification into limited and diffuse skin subsets [2].
Abstract : The platelet-derived growth factor receptor (PDGFR) is a membrane tyrosine kinase receptor involved in several metabolic pathways, not only physiological but also pathological, as in tumor progression, immune-mediated diseases, and viral diseases. Considering this macromolecule as a druggable target for modulation/inhibition of these conditions, the aim of this work was to find new ligands or new information to design novel effective drugs.
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As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
