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To determine whether MN identity contributes to the specificity of connections within the ventral spinal cord, we examined the formation of sensory-motor reflex circuits under conditions where MN organization has been genetically altered. We first traced the central projections of sensory neuron (SN) afferents along the rostrocaudal axis in controls by injecting the lipophilic dye DiI into the dorsal root ganglia (DRGs) of postnatal day (P)0–P1 mice.
Locomotion is a universal behaviour that provides animals with the ability to move between places. Classical experiments have used electrical microstimulation to identify brain regions that promote locomotion1,2,3,4,5, but the identity of neurons that act as key intermediaries between higher motor planning centres and executive circuits in the spinal cord has remained controversial6,7,8,9,10,11,12,13,14.
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