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Chien-Yin Chen

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Articles

Epigenetic reprogramming of T cell metabolism restores function and enhances anti-tumor immunity in lung cancer

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By Yi-chieh Wu, Yu-Ting Lee, Meng-Wei Chou, Shu-Yung Lin, Yu-Ching Wang, Chia-Lang Hsu, Nai-Wen Chang, Hsuan-Hsuan Lu, Yi-Fu Wang, Po-Ju Lee, Hsiao-Jung Kao, Pei-Shan Wu, Miao-Hsia Lin, Li-Chung Hsu, Yen-Ling Chiu, Shih-Yu Chen, Chong-Jen Yu, Hsing-Chen Tsai, Shih-Feng Yang, Sheng-Yao Su, Yi-Jhen Huang, Yi-Hsiu Juan, Chien-Yin Chen
| Nature Verified
Abstract T cell exhaustion represents a critical target for immunotherapy in cancer. Nevertheless, T cells exhibit diminished responsiveness to immune checkpoint inhibitors once they transition to a terminally exhausted state. Here we used an epigenetic drug screen and identified bromodomain and extra-terminal motif inhibitors (BETis) as enhancers of effector functions in primary exhausted T cells (TEX) from malignant pleural effusions in patients with lung cancer.
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