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Chifune Kai

As seen in: Nature
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Articles

Multiancestry genome-wide association and multiomics analyses elucidate spatiocellular features of multiple sclerosis genetics

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By Kotaro Ogawa, Shinichi Namba, Yosuke Ogawa, Ryuya Edahiro, Kyuto Sonehara, Mitsuru Watanabe, Yuya Shirai, Yuji Yamamoto, Go Sato, Tatsuhiko Naito, Akiko Hosokawa, Koichi Matsuda, Fumitaka Shimizu, Makoto Kinoshita, Masahito Mihara, Masayuki Nakamori, Yuko Shimizu, Izumi Kawachi, Katsuichi Miyamoto, Masaaki Niino, Atsushi Kumanogoh, Yuji Nakatsuji, Takuya Matsushita, Hideki Mochizuki, Jun-ichi Kira, Tatsusada Okuno, Noriko Isobe, Yukinori Okada, Rintaro Fujimoto, Shiori Tagawa, Tomohiro Yata, Chifune Kai, Mamoru Yamamoto, Japan MS
| Nature Verified
Abstract Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination disseminated in space and time. Here we performed a genome-wide association study (GWAS) using 688 MS cases and 205,199 controls from the Japanese population and identified significant associations in the major histocompatibility complex region and a population-specific risk variant in 11q24.
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