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Chihiro Tabuchi

As seen in: Nature
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Articles by Chihiro Tabuchi

Diet at disease onset determines tissue inflammatory memory

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By Zewen Jiang, Im-Hong Sun, Longhui Qiu, Dongliang Zhang, Vrinda Johri, Ruriko Watanabe, Mazharul Maishan, Margaret M. Lowe, Sarah Gayer, Nandini Borkar, Jiaxi Wang, Han Yin, Brittany Davidson, Jessica L. Tsui, Nicholas F. Kuhn, Tristan Courau, Sophie Curio, Vinh Nguyen, Abdullah Kurdi, Raymond Cho, Jeffrey Cheng, Katrin J. Svensson, Michael Rosenblum, Mark Looney, Alexis Combes, Ari B. Molofsky, Michael A. Matthay, Sagar P. Bapat, John M. Tayeri, E. Dean Merrill, Chihiro Tabuchi, Arum Yoo, Shin Shyan Chuah, Preetal Deshpande
| Nature Verified
Abstract Obesity, which is often associated with prolonged exposure to an obesogenic diet, substantially alters immunity1,2,3,4,5,6,7, but whether brief dietary changes shape acute inflammatory responses and long-term tissue memory remains unclear. Here we show that transient high-fat diet (HFD) exposure at the onset of acute type 17 skin inflammation exacerbates disease in lean mice to levels comparable to those associated with chronic obesity.
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