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Chinedu Anthony Anene

As seen in: MDPI
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Articles

eRNAs Modulate mRNA Stability and Translation Efficiency to Bridge Transcriptional and Post-transcriptional Gene Regulation

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By Chinedu Anthony Anene, Leeds Beckett, Rene Kuklinkova, Natalia Benova
| biorxiv.org
Abstract Enhancer RNAs (eRNAs) are best known for their role in transcriptional regulation, where they facilitate enhancer-promoter communication and chromatin remodelling. Yet growing evidence suggests that their function may extend beyond the nucleus. Here, we systematically characterise the decay kinetics of eRNAs across human cell types using time-resolved transcriptomics and kinetic modelling.
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Extracellular vesicles from a model of melanoma cancer-associated fibroblasts induce changes in brain microvascular cells consistent with pre-metastatic niche priming.

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By Chinedu Anthony Anene, Jérémie Nsengimana, Mahmoud K. Eldahshoury, Mikayla Shelton
| biorxiv.org
Abstract Malignant melanoma has one of the lowest 5-year survival rates of any cancer, and is recognised for being particularly invasive and metastatic, with the poorest survival outcomes in brain metastases patients. A key characteristic of these tumours is crosstalk between melanoma cells and cells of the tumour microenvironment (TME), such as cancer associated fibroblasts (CAFs).
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Dysregulation of the DRAIC/SBK1 Axis Promotes Lung Cancer Progression

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By Rashed Alhammad, Chinedu Anthony Anene, Milicia Allison, Fares Alhammad
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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