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Chiou-Miin Wang on Muck Rack

Chiou-Miin Wang

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Phagocytosis-initiated tumor hybrid cells acquire a c-Myc-mediated quasi-polarization state for immunoevasion and distant dissemination - Nature Communications

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By Chien-Chin Chen, Michael Liss, Nathaniel Alvarez, Pawel A. Osmulski, Maria Gaczynska, Li-Ling Lin, Kexin Xu, Zhijie Liu, Chun-Liang Chen, Zhao Zhang, Chih-Wei Chou, Cheryl Hsiang-Ling Chiu, Moawiz Saeed, Chiou-Miin Wang, Addanki P. Kumar
| Nature Verified
Abstract While macrophage phagocytosis is an immune defense mechanism against invading cellular organisms, cancer cells expressing the CD47 ligand send forward signals to repel this engulfment. Here we report that the reverse signaling using CD47 as a receptor additionally enhances a pro-survival function of prostate cancer cells under phagocytic attack.
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