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Chiyun Sun on Muck Rack

Chiyun Sun

As seen in: Nature
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Integrating multi-omics analysis reveals shared genetic architecture and spatial correlations between heart failure and osteoporosis

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By Ruikang Liu, Yonghao Li, Jun Li, Nan Jiang, Yanyu Lu, Guangyi Yang, Yuqing Tan, Fuyuan Zhang, Xiao Xia, Yiying Liu, Kai Yang, Menglei Wang, Xiaodi Qi, Xuanchun Huang, Chiyun Sun, Muxi Yu
| Nature Verified
Abstract Heart failure (HF) and osteoporosis (OP) are common age-related disorders with established epidemiological associations, yet their shared genetic architecture and molecular underpinnings remain poorly defined. We performed an integrative multi-omics analysis to elucidate genetic links between HF and OP. Polygenic overlap was quantified using the bivariate causal mixture model (MiXeR), while shared loci were mapped via conditional/conjunctional false discovery rate (cond/conjFDR) analysis.
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