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Pharmaceutics | Free Full-Text | Platelet Activation by Antisense Oligonucleotides (ASOs) in the Göttingen Minipig, including an Evaluation of Glycoprotein VI (GPVI) and Platelet Factor 4 (PF4) Ontogeny
4. Discussion The present study aimed to assess the effects of a panel of ASOs on minipig platelets and investigate the underlying mechanisms for the observed platelet activation and aggregation. An overview of the complete platelet response pattern is presented for both non-rodent species (minipig and NHP) and humans for all seven different ASOs in .
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