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PIH1D2 Loss-of-Function Directs Ciliary and Cell Cycle Defects Resulting in Left Isomerism With or Without Biliary Atresia

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By Alina Kurolap, Gray Faculty, Chofit Chai Gadot
| Wiley Online Library Verified
1 Introduction In normal human anatomy, the position and orientation of thoraco-abdominal organs and major blood vessels exhibit a distinct asymmetry along the body's left–right axis. For example, the heart, aorta, stomach and spleen are positioned on the left side, whereas the inferior vena cava, liver and gall bladder are positioned on the right side. This is referred to situs solitus [1, 2].
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