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Chooi Ying Sim on Muck Rack

Chooi Ying Sim

As seen in: BioRxiv
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Articles

Metabolic Adaptations Rewire CD4 T Cells in a Subset-Specific Manner in Human Critical Illness with and without Sepsis

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By Matthew T. Stier, Allison E. Sewell, Erin L. Mwizerwa, Chooi Ying Sim
| BioRxiv
Abstract Host immunity in sepsis has features of hyperinflammation together with progressive immunosuppression, particularly among CD4 T cells, that can predispose to secondary infections and ineffectual organ recovery. Metabolic and immunologic dysfunction are archetypal findings in critically ill patients with sepsis, but whether these factors are mechanistically linked remains incompletely defined.
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