Chris H Takimoto

Oncolytic virus Macrophage In 2009, the Weissman Laboratory at Stanford identified the cell surface protein CD47 as a compelling anticancer target.1 2 In an elegant series of mechanistic studies, the interaction of CD47 with its cognate receptor, signal regulatory protein-alpha (SIRPα) triggered a potent “don’t eat me signal” to phagocytic immune effector cells including macrophages.