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Articles by Chris Meier
Publisher Correction: Design, structure-based optimization and antiviral evaluation of potent inhibitors for the macrodomain Mac1 of SARS-CoV-2
Correction to: Nature Communications https://doi.org/10.1038/s41467-026-75835-7, published online 27 July 2026 In this article, the single line connecting the “1” and “2” labels in the Figure 1 (ADPR) structure was missing. The figure should have appeared as shown below. The original article has been corrected.
Design, structure-based optimization and antiviral evaluation of potent inhibitors for the macrodomain Mac1 of SARS-CoV-2
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Abstract Enzymatically active macrodomains of (+)ss-RNA viruses mediate immune evasion by countering ADP-ribosylation and are therefore promising druggable targets. Here we report testing of ADP / ADP-ribose analogues for their ability to inhibit Mac1 of SARS-CoV-2, measurement of the affinity of active compounds and characterization of their binding mode by cocrystallization, uncovering critical molecular determinants of protein-ligand interaction.
By Maximilian Sandmann, Simon Sander, David Carrillo, Benedikt Ganter, Celine J. Fischer, Neele Pekarek, Julia M. Berger, Toni Luise Meister, Bruno Canard, Joanna M Watt, Barry Potter, Chris Meier, Sahra Tajdar, Marina Ocenas, Stefanie Etzold, Barbara Selisko, Maria Garcia Alai, Tidow Henning, Pfefferle Susanne, Ralf Fliegert
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Nature
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Membrane-Permeable Nucleoside T-1106 Diphosphate and Triphosphate Analogues as Antiviral Pronucleotides
1 Introduction The frequent emergence of zoonotic RNA viruses, such as avian influenza, Zika, Ebola and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is associated with significant morbidity and mortality [1-3]. Besides, seasonal influenza A (IAV) and influenza B (IBV) viruses account each year for ∼290,000 to 650,000 deaths worldwide [4]. To complement vaccines, effective antiviral drugs must at all times be available, with broad-acting agents having a clear advantage.
What GenAI Means for Health Care Investors
Generative artificial intelligence (GenAI) is poised to transform the health care industry. It is already beginning to have an impact in fields ranging from R&D to care delivery to precision medicine. GenAI is typically defined as a set of algorithms capable of producing seemingly new content such as text, images, audio, and video derived from a vast quantity of unlabeled data. GenAI is poised to transform the health care industry.
14 Top Software Developer Skills for 2024: The Complete Guide
Are you looking to enhance your software developer skills in 2024? This guide covers the must-have skills, from programming languages to cloud computing, that will keep you competitive in the tech world. Key Takeaways Mastering core programming languages like Python, JavaScript, and Java is essential, with a special focus on frameworks for front-end and mobile development.
Out of the Dark, into the Light: Metabolic Fluorescent Labeling of Nucleic Acids
Introduction In the intriguing domain of chemical biology, live-cell imaging has emerged as a powerful tool, enabling the visualization of nucleic acids, which will increase the understanding of the mechanisms involved in DNA- or RNA-related biological processes. One example of high interest are dynamic interactions between cellular and viral components during, e. g., replication within living systems.
Out of the Dark, into the Light: Metabolic Fluorescent Labeling of Nucleic Acids
This review outlines recent advances in live-cell imaging techniques for nucleic acids. We describe the evolution of these methods, particularly highlighting the development of metabolic labeling approaches compatible with living systems using fluorescence-based labeling.
Web Developer Soft Skills: The Essential Guide for Career Growth
In the evolving landscape of web development, mastering programming languages and technical skills is just one side of the coin. Equally important are the soft skills that enable web developers to navigate their career paths successfully. Skills such as effective communication, problem-solving, and adaptability not only improve job performance but also open doors to new opportunities and career growth.
Lipophilic Nucleoside Triphosphate Prodrugs of Anti‐HIV Active Nucleoside Analogs as Potential Antiviral Compounds
1 Introduction The human immunodeficiency virus (HIV) is a retrovirus that infects and destroys the immune cells that lead to acquired immune deficiency syndrome (AIDS).[1-4] According to the World Health Organization (WHO) on HIV/AIDS report 2022 ≈39 million people are living with HIV/AIDS, including 1.3 million new infections and 0.63 million people died from HIV/AIDS-related diseases, especially in third-world countries.
A Triphosphate Pronucleotide (TriPPPro) Reporter with Optimized Cell‐Permeable Dyes for Metabolic Labeling of Cellular and Viral DNA in Living Cells
Abstract The metabolic labeling of nucleic acids in living cells is highly desirable to track the dynamics of nucleic acid metabolism in real-time and has the potential to provide novel insights into cellular biology as well as pathogen-host interactions. Catalyst-free inverse electron demand Diels-Alder reactions (iEDDA) with nucleosides carrying highly reactive moieties such as axial 2-trans-cyclooctene (2TCOa) would be an ideal tool to allow intracellular labeling of DNA.
Pronucleotides of 2′,3′-Dideoxy-2′,3′-Didehydrothymidine as Potent Anti-HIV Compounds
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Med. Chem. 2023, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
3 Strategies for Smooth Healthcare Construction Projects
Addressing challenges requires that managers work closely with multiple stakeholders, including administrators, facility staff members, subcontractors and crews. By Chris Meier In a rapidly shifting economy, the healthcare industry is shifting, too. As the pandemic drives massive changes in technology and consumer preferences, many healthcare systems are reimagining their campuses by building alternative care models and expanding into new communities.
Adopting AI in Drug Discovery
Related Expertise: Biopharma, Health Care Industry, Artificial Intelligence March 29, 2022 By Margaret Ayers, Madura Jayatunga, John Goldader, and Chris Meier Delivering on the promise requires action on five strategic and operational tracks. Artificial intelligence has been making inroads in drug discovery for a good part of the last decade.
Photocaged and Mixed Photocaged Bioreversible‐Protected ATP Derivatives as Tools for the Controlled Release of ATP
Abstract For a better understanding of ATP‐depending extra‐ and intracellular processes, a series of new chemical tools for the potential investigation of such processes was developed. We synthesized ATP derivatives with either two photocleavable masks or one photocleavable and one bio‐removable mask. The quantitative release of ATP from these compounds was proven by photolysis and by esterase incubation using HPLC‐monitoring.
How to Do Keyword Research for the App Store
The use of app store keywords is a vital component in the successful promotion of your app, making it discoverable to users who aren’t aware of your business, or that your business has its own mobile app. Apple provides a dedicated field for adding keywords to your app store listing, while Google pulls keywords from your app description, and other elements of your app store listing.
Letter: Thanks for your support of the Fargo Little League team
On behalf of the team, the coaching staff, and everyone associated with Fargo Youth Baseball, we would like to recognize the amazing support for this group from the Fargo-Moorhead-West Fargo community.
How to Optimise Your Business for Mobile
It is becoming increasingly difficult for business owners to ignore mobile, and that’s good. Ten years after the launch of the first iPhone, more than half the mobile phones currently in use are smartphones. And two years have passed since Google first announced that the number of searches taking place on a mobile device exceeds those taking place on a computer. Despite this, one doesn’t need to look very hard to find businesses that are still not optimised for mobile.
Class of 2017: The Best New Apps This Year
When the Apple App Store launched in July 2008, it only offered users access to 500 apps. By July 2009 this number had grown to more than 50,000, a few months before the Android Market relaunched as the Google Play Store with 16,000 apps available. As of March 2017, the Google Play Store has 2.8m apps available, with Apple’s App Store offering 2.2m apps. More than 30,000 new apps are released each month, but that shouldn’t discourage new app developers.
How to Optimise Your Business for Mobile - AppInstitute
It is becoming increasingly difficult for business owners to ignore mobile, and that’s good. Ten years after the launch of the first iPhone, more than half the mobile phones currently in use are smartphones. And two years have passed since Google first announced that the number of searches taking place on a mobile device exceeds those taking place on a computer. Despite this, one doesn’t need to look very hard to find businesses that are still not optimised for mobile.
WhatsApp's Jan Koum
Unlike the other app builders we have previously written about, Jan Koum lives a life that is much more low-profile. This is all the more incongruous given the fact that he created the second most used app in the world: WhatsApp. But as you learn more about Koum, you discover that it is perfectly in character. Fame and fortune are two concepts that have never interested him.
Why Restaurants Need Mobile Apps: 12 HUGE Benefits
The number of valid reasons small businesses can offer up for not having a mobile app decrease each year. And if it is fear or apathy that are holding you back, you should ask yourself what fear and apathy have done for your business so far. By now, you should be quite familiar with many of the statistics relating to smartphones and internet usage: In business you are told to “know your customer”, and this extends to understanding their behaviour.
How to Make Money Selling Apps
Small businesses have – in the past – been wary about launching a dedicated mobile app. High costs, and the technical skill required, contributed to this weariness, with a 2016 survey suggesting that only 20% of small businesses currently have a mobile app. But costs have fallen dramatically, and apps can now be launched with considerably more ease, creating a sizable market for anyone who wants to make money selling apps.
How Did Uber Start? The Story Behind Founder Travis Kalanick
Uber Technologies Inc. was founded as UberCabs in March 2009 and is now more commonly known simply as Uber. Of the three original co-founders, only Garrett Camp and Travis Kalanick remain, with Oscar Salazar having amicably left in 2011, soon after Uber’s services and mobile app officially launched in San Francisco. Following an initial seed investment of $200,000, Uber has gone on to raise more than $6-billion, while revenue in 2015 topped $1.5-billion.
Essential Mobile App Marketing Guide for Small Businesses
One of the best benefits of having a mobile app for your small business is that it is almost like having an open-line to each of your customers; a means for you and your customers to communicate directly with each other. And part of this communication should, naturally, be in the form of marketing, except now you don’t have to worry too much about whether your message is actually reaching your customers.
27 Christmas Marketing Ideas for Small Businesses
Regardless of what your preferred marketing channel is, we have put together a list of 27 Christmas marketing ideas you can use to add some sparkle to your holiday marketing and sales strategy. There is still enough time to implement many of these ahead of this Christmas, and for those that require a little more planning, you have around 52 weeks left to finalise them for next Christmas.
20 Twitter Accounts Every Small Business Should Follow - AppInstitute
With its rapidly updating feed, Twitter can be a great source of news and information for anyone, not just small business owners. But follow too many people and it becomes difficult to find the value in between the mundane. One of the best solutions for small business owners is to add the accounts that matter the most to lists, and then switch between your lists when your Twitter feed becomes too unruly.
Rachel Morello headshot
None, I do not identify with any political party
The Why, How and What of a Content Audit
Two words, used together, guaranteed to get your content and development teams grumbling are content audit. Casually mention them during a weekly meeting, and you may find yourself an unwilling participant in a reenactment of The Crimson Permanent Assurance. The simple truth is that there are some people who love auditing, and then there’s the rest of us.
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