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Abstract Volatile Organic Compounds (VOCs) offer potential for non-invasive diagnosis as biomarkers of disease and metabolism. In complex biological matrices, such as breath however, identifying useful biomarkers from hundreds, or even thousands of VOCs can be challenging. Models of disease, such as cellular or animal models, offer a means to elucidate VOC metabolisms, for accurate targeted studies in patient samples.
Chris Ugbode, Laura Fort-Aznar and Sean T. Sweeney1 Department of Biology, University of York, York YO10 5DD, United Kingdom ↵1 To whom correspondence should be addressed. E-mail: sean.sweeney{at}york.ac.uk. Edited by Ursula Jakob Abstract The inter- and intracellular propagation of aggregated proteins like tau is emerging as a central mechanism behind progression of various neurodegenerative diseases. The steps by which tau aggregates and propagates is currently unclear. Chen et al.
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