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Christella E Widjaja on Muck Rack

Christella E Widjaja

As seen in: The Journal of Immunology
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Articles

Proteasome degradative activity regulates CD8+ T lymphocyte metabolism and fate specification

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By Patrick J Metz, Christella E Widjaja, Yves Leestemaker, Jeffrey N Savas, Anthony T Phan
| The Journal of Immunology Verified
During an immune response to microbial infection, CD8+ T lymphocytes can undergo asymmetric division, giving rise to daughter cells that exhibit distinct tendencies to adopt the terminal effector and memory fates. Here we show that ‘pre-effector’ and ‘pre-memory’ cells arising from the first CD8+ T cell division in vivo exhibit low and high rates of proteasome degradative activity, respectively.
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