Christian Barro
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NfL and pNfH are increased in Friedreich’s ataxia
NfL and pNfH are increased in Friedreich’s ataxia Mots clés Neurofilament light chain NfL Friedreich's ataxia Biomarker Neurofilament heavy chain pNfH Fichier principal s00415-020-09722-6.pdf (825.62 Ko) Télécharger le fichier Origine : Publication financée par une institution Licence : CC BY - Paternité
Accuracy of serum neurofilament light to identify contrast-enhancing lesions in multiple sclerosis
Abstract Contrast-enhancing magnetic resonance imaging (MRI) lesions (CELs) indicate acute multiple sclerosis inflammation. Serum biomarkers, neurofilament light (sNfL), and glial fibrillary acidic protein (sGFAP) may increase in the presence of CELs, and indicate a need to perform MRI. We assessed the accuracy of biomarkers to detect CELs. Patients with two gadolinium-enhanced MRIs and serum biomarkers tested within 3 months were included ( = 557, 66% female).
Serum GFAP and NfL Levels Differentiate Subsequent Progression and Disease Activity in Patients With Progressive Multiple Sclerosis
Statistical Analyses Continuous variables were described by median and interquartile range and categorical variables by percentages. The biomarker levels were log transformed for the analyses to reduce the skewness of the distribution. Using the baseline sNfL and sGFAP measurements, the association between the log-transformed values was estimated using the Pearson correlation coefficient.
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