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Christian Bartens

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Structure and function of the geldanamycin amide synthase from Streptomyces hygroscopicus - Nature Communications

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By Wiebke Ewert, Carsten Zeilinger, Matthias Preller, Christian Bartens
| Nature Verified
Abstract Amide synthases catalyze the formation of macrolactam rings from aniline-containing polyketide-derived seco-acids as found in the important class of ansamycin antibiotics. One of these amide synthases is the geldanamycin amide synthase GdmF, which we recombinantly expressed, purified and studied in detail both functionally as well as structurally. Here we show that purified GdmF catalyzes the amide formation using synthetically derived substrates.
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