Christian E Rocheleau on Muck Rack

Christian E Rocheleau

Montreal
We’re a research group at McGill University using the nematode C. elegans to study endocytosis and cell signaling.
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Articles

ALG-1, a microRNA argonaute, promotes vulva induction in C. elegans

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By Christian E Rocheleau, Sunny Zhen
| biorxiv.org
Abstract Signaling by the LET-60 Ras GTPase/MPK-1 Extracellular Regulated Kinase pathway specifies the vulva cell fate in C. elegans. The let-7 miRNA family negatively regulates LET-60 Ras but other miRNAs can also modulate vulva induction. To determine the impact of globally reducing miRNA function on LET-60 Ras-mediated vulva induction we analyzed the effect of loss of the ALG-1 miRNA regulator on vulva development.
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Centralspindlin promotes C. elegans anchor cell specification, vulva induction and morphogenesis

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By Tatsuya Kato, Olga Skorobogata, Christian E Rocheleau
| biorxiv.org
Abstract Caenorhabditis elegans vulval development is a relatively simple model of organ development whereby a signal from the overlying gonad induces three epithelial cells to undergo three rounds of cell division to generate 22 cells that make up the vulva. Specification of the vulva cell fates requires coordination between cell division and cell signaling via LIN-12/Notch and LET-23/EGFR pathways in the somatic gonad and the underlying epithelium.
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