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Christina Bartuscha on Muck Rack

Christina Bartuscha

As seen in: American Society for Microbiology (ASM)
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Articles

Hepatitis B Virus Subverts the Autophagy Elongation Complex Atg5-12/16L1 and Does Not Require Atg8/LC3 Lipidation for Viral Maturation

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By Lisa Zeyena, Christina Bartuscha, Tatjana Döring, Lisa Zeyen
| American Society for Microbiology (ASM)
Previous studies indicated that hepatitis B virus (HBV) stimulates autophagy to favor its production. To understand how HBV co-opts autophagy as a proviral machinery, we studied the roles of key autophagy proteins in HBV-replicating liver cell cultures. RNA interference-mediated silencing of Atg5, Atg12, and Atg16L1, which promote autophagophore expansion and LC3 membrane conjugation, interfered with viral core/nucleocapsid (NC) formation/stability and strongly diminished virus yields.
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