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Christina DeBarro on Muck Rack

Christina DeBarro

As seen in: BioRxiv, Cell Reports Physical Science
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Articles

Defining the importance of the arginine loop region of protegrin-1 for antimicrobial activity towards colistin-resistant Klebsiella pneumoniae.

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By Christina DeBarro, Noor Radde, Sofia Assent, Hannah Makhecha
| BioRxiv
Abstract Carbapenem resistant Klebsiella pneumoniae extreme drug resistance has warranted the use of colistin as a last-resort antibiotic but these isolates are now displaying increasing rates of colistin resistance. This is in large part due to the modifications made to the lipid A by the PhoPQ two component system.
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Polyproline peptide targets Klebsiella pneumoniae polysaccharides to collapse biofilms

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By Robert Beckman, James E. Keener, Marcelo Torres, Christina DeBarro
| Cell Reports Physical Science Verified
Highlights • Confocal imaging visualizes the released cells and collapse of the biofilm matrix • Truncated analogs reveal polysaccharide interactions drive the matrix disruption • Mass spectrometry describes the polysaccharide interaction region of bac7 (1–35) • Topical application using a skin abscess model decreases the bacterial burden in vivo Summary Hypervirulent Klebsiella pneumoniae is known for its increased extracellular polysaccharide production. Biofilm matrices of hypervirulent K.
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