Darren Ali says the only warning sign that he was going to suffer a “widowmaker" while otherwise healthy at age 45 was some upper back pain. Then, three months later, he had a massive heart attack. "It's almost like an elastic band's tightening inside your chest," said Ali, now 52, who lives in Maple Ridge, B.C. Had Ali taken a simple blood test earlier in life, he might have known that he has high levels of a genetically-determined, cholesterol-carrying particle circulating in his bloodstream.