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Articles by Christine Rangger
68Ga-Labeled Glycopeptides as Effective Tools for Liver Function Imaging
Introduction Click to copy section linkSection link copied! Functional liver imaging addressing the asialoglycoprotein receptor (ASGR) status has gained increased value for disease monitoring because ASGR expression correlates inversely with the progression of various liver-specific diseases such as steatotic liver disease, cirrhosis, and hepatocarcinoma.
68Ga-Labeled TRAP-Based Glycoside Trimers for Imaging of the Functional Liver Reserve
Introduction Click to copy section linkSection link copied! Over the past few years, multimeric ligand concepts have gained increased popularity in the field of nuclear medicine as they can have a bunch of favorable properties such as increased hydrophilicity, improved stability, and elevated affinity compared to the monomeric conjugate. (1−3) However, a robust prediction of the behavior of these compounds based solely on the chemical structure stays rather vague.
Automated Production of [68Ga]Ga-Desferrioxamine B on Two Different Synthesis Platforms
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Automated Production of [68Ga]Ga-desferrioxamine B on Two Different Synthesis Platforms
Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 26 July 2024 / Approved: 29 July 2024 / Online: 29 July 2024 (08:43:23 CEST) Kraihammer, M.; Petřík, M.; Rangger, C.; Gabriel, M.; Haas, H.; Nilica, B.; Virgolini, I.; Decristoforo, C. Automated Production of [68Ga]Ga-desferrioxamine B on Two Different Synthesis Platforms. Preprints 2024, 2024072268.
Effect of N-Terminal Peptide Modifications on In Vitro and In Vivo Properties of 177Lu-Labeled Peptide Analogs Targeting CCK2R
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Multimerization results in formation of re-bindable metabolites: A proof of concept study with FSC-based minigastrin imaging probes targeting CCK2R expression
Synthesis of MG-analogues, extraction, derivatization and demetallation of the chelating backbone was straight forward following a well-established in house protocol. Conjugation of up to three targeting vectors was conducted site specifically utilizing maleimide-thiol crosslink reaction. Resulting conjugates were obtained in good yield, excellent chemical purity (> 95%; analytical RP-HPLC, UV absorption at λ = 220 nm) and mass analysis was in good agreement with the calculated values.
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