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Articles by Christopher Fields
Corisin induces proteostasis stress to drive epithelial injury and pulmonary fibrosis
Abstract Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disease lacking clarity on the mechanisms linking epithelial injury to fibrotic remodeling. Here, we identify the microbiota-derived corisin as a potent, multifaceted driver of epithelial injury and pulmonary fibrosis.
Polycomb-mediated 3D-genome organization controls replication timing
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Polycomb (PcG) bodies are nuclear foci formed by polycomb protein complexes that contain PcG-bound DNA and are implicated in gene regulation during development and differentiation, although their precise molecular function remains unclear.
External validation improves generalizability, replicability and reproducibility in predictive models for neuroimaging
Abstract Poor generalizability continues to hinder mapping brain activity to behavior using human neuroimaging data. A potential solution is predictive modeling, which evaluates generalizability in unseen data from the same dataset. However, predictive models often fail external validation—a stricter test of generalizability involving evaluation in an independent dataset.
Longitudinal and Geographic Trends in Perceived Racial Discrimination Among Adolescents in the U.S.: The Adolescent Brain Cognitive Development (ABCD) Study
The authors have declared no competing interest. The Adolescent Brain Cognitive Development (ABCD) Study was supported by the National Institutes of Health and additional federal partners under awards U01DA041022, U01DA041025, U01DA041028, U01DA041048, U01DA041089, U01DA041093, U01DA041106, U01DA041117, U01DA041120, U01DA041134, U01DA041148, U01DA041156, U01DA041174, U24DA041123, and U24DA041147.
High‐quality genome assemblies for nine non‐model North American insect species representing six orders (Insecta: Coleoptera, Diptera, Hemiptera, Hymenoptera, Lepidoptera, Neuroptera)
1 INTRODUCTION Improved DNA sequencing technologies have greatly reduced the cost of obtaining high-quality de novo genome assemblies for non-model organisms including insects, which present unique challenges due to their small body sizes, difficulty in identification of field-collected specimens and the lack of reference genomes for many diverse insect groups.
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