Pin-Kuan Chiang on Muck Rack

Pin-Kuan Chiang

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Articles

Patient-derived organoids across cancers reveal conserved tumor heterogeneity and actionable therapeutic vulnerabilities

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By Pascal J. Schmidt, Neha Chetlangia, Pin-Kuan Chiang, Hui-Hsuan Kuo, Bhavneet Bhinder, Hamza N Gokozan, Kathryn Gorski, Pooja Chandra, Jyothi Manohar, Daniela Guevara Verified, John Otilano, Jenna Moyer, Marvel Tranquille, Sarah Ackermann, Jared Capuano, Cynthia Cheung, Thomas A. Caiazza, Phoebe L. Reuben, Anastasia Tsomides, Adriana Irizarry, Michael Sigouros, David Wilkes Verified, Abigail King Verified, Troy Kane, Majd Al Assaad
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract We developed a pan-cancer patient-derived organoid (PDO) platform comprising 220 PDOs from 191 patients across 15 cancer types to advance functional precision oncology.
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Nanoscale frictional imaging of ferroelectric domains

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By Pascal J. Schmidt, Neha Chetlangia, Pin-Kuan Chiang, Seongwoo Cho, Hyeonbin Moon, Iaroslav Gaponenko, Eunnuri Cho, Céline Lichtensteiger, Ruben Dragland, Jan Schultheiß, Dennis Meier, Seunghwa Ryu, Seungbum Hong, Patrycja Paruch
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Nanoscale control of electromechanical coupling transforms frictional information into a direct probe of ferroelectric polarization.
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NLRP3 haploinsufficiency unmasks a compensatory NLRP1-NLRP3 interaction that drives accelerated aging in mice

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By Pascal J. Schmidt, Neha Chetlangia, Pin-Kuan Chiang, Ines Muela-Zarzuela, Elísabet Alcocer-Gómez, Juan M. Suarez-Rivero, Evon Low, Abbas Ishaq, Mikel Azkargorta, Amparo Luque-Sierra, Franz Martín, Felix Elortza, Antonio Astorga-Gamaza, Rosa Anton, Sofia Bali, Joaquín Tamargo-Azpilicueta, Alejandra Guerra-Castellano, Irene Díaz-Moreno, Lukasz A. Joachimiak, Javier Oroz, Jesús Ruiz-Cabello, Thomas von Zglinicki, Alberto Sanz Verified, Mario D. Cordero
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The NLRP3 inflammasome has been implicated in a wide range of human diseases, including cardiovascular, metabolic, neurodegenerative (such as Alzheimer’s disease), and other age-related conditions. This has positioned NLRP3 as a promising pharmacological target.
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