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Highlights • Ductal Ngn3+ cells contribute to the beta cell population during homeostasis • Duct-resident endocrine progenitor cells express somatostatin • Somatostatin-positive ductal cells are increased in Akita+/− diabetic mice • scRNA-seq analysis suggests ductal somatostatin+ cells give rise to beta cells Summary Ductal cells have been proposed as a source of adult β cell neogenesis, but this has remained controversial.
Abstract Tubular epithelia are a basic building block of organs and a common site of cancer occurrence1,2,3,4. During tumorigenesis, transformed cells overproliferate and epithelial architecture is disrupted. However, the biophysical parameters that underlie the adoption of abnormal tumour tissue shapes are unknown.
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