Christopher Griffith

AR androgen receptor IHC immunohistochemistry PA pleomorphic adenoma SCC squamous cell carcinoma SCS salivary carcinosarcoma SDC salivary duct carcinoma Introduction Salivary duct carcinoma (SDC) is a rare, aggressive salivary gland carcinoma that commonly arises in major salivary glands and typically affects males in the fifth decade of life and older.

1 INTRODUCTION In patients with oral cavity squamous cell carcinoma, lymph node involvement with extranodal extension (ENE) is found in up to 20% of patients at the time of their initial surgery.1 The presence of ENE in these patients is associated with a higher risk of distant metastasis and worse overall survival.2 Pooled analysis and long-term follow up of two prospective randomized controlled trials (RTOG 9501 and EORTC 22931) show that patients with locally advanced head and neck cancer...