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The Blood-Brain Barrier (BBB) Score

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By Mayuri Gupta, Donald F. Weaver, Hyeok Jun Lee, Christopher J. Barden
| American Chemical Society
The blood–brain barrier (BBB) protects the brain from the toxic side effects of drugs and exogenous molecules. However, it is crucial that medications developed for neurological disorders cross into the brain in therapeutic concentrations. Understanding the BBB interaction with drug molecules based on physicochemical property space can guide effective and efficient drug design.
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